Quantifying the Cure: How FMTVDM® Measures Real Treatment Success
- Richard M Fleming, PhD, MD, JD
- Oct 24
- 3 min read
Updated: Oct 25
Introduction: Moving Beyond Guesswork in Medicine
Every patient wants to know one thing after treatment begins:
“Is it working?”
For most diseases — whether heart disease, infection, inflammation, or cancer — medicine still relies on guesswork. Clinicians interpret changes in size, brightness, or patient symptoms, but rarely measure the biologic change itself.
FMTVDM® (Fleming Method for Tissue and Vascular Differentiation and Metabolism) replaces uncertainty with quantifiable truth. By measuring functional change at the tissue level, it reveals whether treatment is truly working — long before visible size or shape changes occur.
The Problem: Visual Changes Don’t Equal Healing
Imaging technologies like CT and MRI show anatomy, not physiology. A tumor that “looks smaller” may still be metabolically active; a heart that “appears normal” may still be ischemic.
Even PET scans — though metabolic — are often interpreted qualitatively, using nonstandard “SUV” measurements that vary from camera to camera and patient to patient.
Without calibration, these readings are not reproducible — and therefore, not scientific evidence.
FMTVDM® corrects this by calibrating each imaging system, converting it into a quantitative measuring instrument capable of distinguishing real biologic change from visual illusion.
FMTVDM®: Measuring Treatment Effectiveness
FMTVDM® is unique because it measures the physiology of recovery, not merely the structure.
Step-by-Step:
Baseline Quantification: Before treatment, FMTVDM® quantifies the degree of tissue activity — defining how “diseased” the tissue is on a measurable scale.
Post-Treatment Re-Measurement: After intervention, FMTVDM® quantifies the same tissue again.
Comparative Analysis: The measured difference reflects the actual physiologic change, providing objective evidence of therapeutic effect.
This approach has been validated in multiple clinical studies, including:
Fleming RM. FMTVDM Measurement of Coronary Blood Flow and Treatment Response. J Nucl Cardiol. 2018;25(3):1–9.
Fleming RM. Quantitative Measurement of Inflammation and Cancer Therapy Response Using FMTVDM. J Nucl Med Radiat Ther. 2017;8(3):1–8.
These peer-reviewed works show that FMTVDM® can quantify improvement in coronary artery disease, infections, and cancer — establishing true, measurable endpoints for medical success.
Quantification Changes Everything
By measuring treatment response numerically, FMTVDM® eliminates the subjectivity that has long plagued clinical trials and patient care.
For Physicians: It means knowing whether an intervention is truly reversing disease.
For Researchers: It means reproducible, quantifiable data that can be compared globally.
For Patients: It means knowing, with certainty, whether the therapy is working.
FMTVDM® shifts the question from “Does it look better?” to “Is it getting better?” — and provides the scientific answer.
Clinical Applications Across Medicine
FMTVDM® has demonstrated quantitative benefits in multiple domains:
Cardiology: Measures perfusion improvement after angioplasty or medication therapy.
Oncology: Quantifies metabolic reduction in cancerous lesions following chemotherapy or radiation.
Infectious Disease: Tracks resolution of infection and inflammation, distinguishing active disease from residual scarring.
Vascular Health: Evaluates endothelial recovery — the earliest measurable sign of restored function.
Each use case demonstrates the same principle: truth must be measured.
FMTVDM® Defines Real Outcomes
In a world where medical claims and data often conflict, quantification is the only safeguard against assumption.
FMTVDM® not only verifies that a treatment has effect — it defines the degree of success, giving physicians and patients the scientific foundation to make informed decisions.
By transforming imaging into a measurable scale of health and disease, FMTVDM® provides the first reproducible clinical method for quantifying cure.
Key Takeaways
✅ Visual changes are not always real recovery.
✅ FMTVDM® measures true physiologic improvement.
✅ Quantification ensures reproducible, global standards.
✅ Treatment success becomes measurable — not assumed.
✅ FMTVDM® defines the world’s first quantitative scale for medical truth.
References
Fleming RM. FMTVDM Measurement of Coronary Blood Flow and Treatment Response. J Nucl Cardiol. 2018;25(3):1–9.
Fleming RM. Quantitative Measurement of Inflammation and Cancer Therapy Response Using FMTVDM. J Nucl Med Radiat Ther. 2017;8(3):1–8.
Fleming RM. U.S. Patent No. 9,566,037 B2 — Method for Measuring Differences in Tissue and Vascular Activity.
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